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Title   전립선 선암종에서의 TGF-β1 과 TGF-β2 의 발현 ( The Expression of TGF-β1 and TGF-β2 in Prostatic Carcinoma )
Publicationinfo   1998 Jan; 030(05): 970-980.
Key_word   Prostate, Carcinoma, TGF-￥a1, TGF-￥a2
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Abstract   Transfonning growth factor-￥a (TGP-￥a) is a multipotent growth factor affecting development, homeostasis, and tissue repair. We evaluate the significance of the expression of TGF-￥a1 and TGF-￥a2 and correlation with prognostic factors in prostate cancer. Materials and Methods: In order to investigate the expression of TGF-￥a1 and TGF-￥a2, we analyzed Immunohistochemical staining from paraffin blocks of 22 cases of the prostate carcinoma and adjacent normal prostate. Results: The expressions of TGF-￥a1 and TGF-￥a2 were noted in the cytoplasm of tumor cells, normal epithelial cells and stroma. The staining intensity and areas were examined and scored from 0 to 5. The TGF-￥a1 staining scores of the tumor cells were higher than that of the adjacent normal epithelial cells (p=0.001). The TGF-￥a2 staining scores of the tumor cells were also higher than that of the adjacent normal epithelial cells (p=0.003). However, there were no correlation between tumor surrounding stroma and normal stroma in TGF-￥a1 and TGF-￥a2 staining scores. The serum PSA level, the clinical stage, the Gleason score and the lymph node metastasis of the tumor did not correlated with the staining score of TGF-￥a1 and TGF-￥a2. Conclusion: These results indicate that the prostatic cancer was associated with alteration of TGF-￥a1 and TGF-￥a2 expression by prostatic epithelial cells which play a role in prostatic carcinogenesis.
저 자   김기권(Ki Kwon Kim),김정란(Jung Ran Kim),김동훈(Dong Hoon Kim),장태정(Tae Jung Jang),이종임(Jong Im Lee),이경섭(Kyung Sub Lee)